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Position	GPCRdb num	Variant	Variant ID	AA change	Allele frequency	Allele count	Allele number	Functionally relevant site	SIFT score	PolyPhen-2 score	Unified Impact Prediction	PTM site	Num. associated diseases
3		T - N	rs746562618	similar					0.18	0.006	Benign		0
7		T - S	rs1441554534	similar					0.41	0	Benign		0
8		P - S	rs149355664	changed	3.180e-05	1	31404		0.13	0.232	Benign		0
8		P - T	rs149355664	changed					0.13	0.232	Benign		0
12		Y - H	rs144707166	changed					0.15	0	Benign		0
14		E - D	rs1170265741	similar	3.180e-05	1	31408		0.6	0.111	Benign		0
15		V - A	rs1371072537	similar	3.190e-05	1	31392		0.57	0.021	Benign		0
17		Y - H	rs1314818160	changed					0.57	0	Benign		0
17		Y - C	rs759746124	changed					0.17	0.379	Benign		0
18	1x24	E - K	rs1215961508	changed					0.2	0.055	Benign		0
23	1x29	T - A	rs756098186	changed					0.87	0	Benign		0
26	1x32	R - W	rs367971570	changed					0.23	0	Benign		0
26	1x32	R - Q	rs778561198	changed					0.57	0.001	Benign		0
27	1x33	I - L	rs372491689	similar					0.04	0.53	Indef.		0
31	1x37	V - A	rs779904780	similar					0	0.393	Indef.		0
31	1x37	V - G	rs779904780	changed					0	0.393	Indef.		0
32	1x38	V - A	rs375488620	similar					0.02	0.524	Indef.		0
40	1x46	G - R	rs749741937	changed					0	0.986	Damaging		0
41	1x47	V - L	rs1433309571	similar					0.07	0.167	Benign		0
43	1x49	G - S	rs771532073	changed					0	0.999	Damaging		0
43	1x49	G - R	rs771532073	changed					0	0.999	Damaging		0
52	1x58	G - R	rs937336175	changed					0	0.996	Damaging		0
54	1x60	R - P	rs192933693	changed				Intracellular binding site	0	0.979	Damaging		0
54	1x60	R - W	rs267605624	changed	6.370e-05	2	31384	Intracellular binding site	0	0.427	Indef.		0
54	1x60	R - Q	rs192933693	changed	3.190e-05	1	31378	Intracellular binding site	0	0.979	Damaging		0
55		M - I	rs1241184926	similar					0	0.985	Damaging		0
56		T - I	rs368955062	changed	6.370e-05	2	31382		0.02	0.188	Indef.		0
57		R - G	rs142611552	changed					0.04	0.127	Indef.		0
57		R - C	rs142611552	changed	3.190e-05	1	31380		0.04	0.127	Indef.		0
57		R - H	rs750225501	similar					0.48	0.031	Benign		0
58	2x37	T - P	rs758222403	changed				Intracellular binding site	0	0.997	Damaging		0
61	2x40	T - I	rs1470340076	changed				Intracellular binding site	0.02	0.787	Indef.		0
62	2x41	I - F	rs1176402586	changed					0	0.934	Damaging		0
64	2x43	Y - C	rs1400663583	changed	3.190e-05	1	31366	Intracellular binding site	0	0.994	Damaging		0
68	2x47	A - V	rs1319424621	similar					0	0.999	Damaging		0
70	2x49	A - V	rs147205221	similar					0	0.99	Damaging		0
73	2x52	S - F	rs771316672	changed	6.370e-05	2	31400		0.33	0.049	Benign		0
74	2x53	F - L	rs74602258	changed	4.619e-03	145	31394	Binding site	0	0.732	Indef.		0
75	2x54	T - M	rs144552448	changed	3.190e-05	1	31392		0.13	0.298	Benign		0
76	2x55	A - T	rs376191217	changed	3.180e-05	1	31398		0.16	0.119	Benign		0
77	2x56	T - I	rs775845526	changed				Binding site	0.22	0.117	Benign		0
78	2x57	L - S	rs1271296719	changed					0	0.995	Damaging		0
82	2x61	I - V	rs553531100	similar	3.190e-05	1	31360		0.23	0.009	Benign		0
84	2x63	S - F	rs865881247	changed	3.190e-05	1	31386	Binding site	0.06	0.285	Benign		0
85	2x64	M - T	rs765433312	changed	3.190e-05	1	31384	Binding site	0.56	0.006	Benign		0
85	2x64	M - I	rs572059287	similar	3.190e-05	1	31384	Binding site	0.31	0.003	Benign		0
91	23x50	W - G	rs1365783203	changed				Binding site	0	0.999	Damaging		0
92	23x51	P - S	rs766221747	changed					0	0.988	Damaging		0
92	23x51	P - L	rs1336959824	changed					0.11	0.4	Benign		0
92	23x51	P - T	rs766221747	changed					0	0.988	Damaging		0
98	3x25	C - R	rs754553038	changed	3.190e-05	1	31392	Binding site	0.02	0.999	Damaging	Disulfide Bond	0
104	3x31	V - A	rs755580928	similar					0.02	0.033	Indef.		0
104	3x31	V - L	rs199862216	similar					0.26	0.029	Benign		0
104	3x31	V - M	rs199862216	similar	3.180e-05	1	31398		0.26	0.029	Benign		0
107	3x34	I - V	rs746314594	similar					0.09	0.044	Benign		0
107	3x34	I - S	rs377196157	changed					0	0.783	Indef.		0
108	3x35	N - K	rs747440795	changed				Binding site	0	0.995	Damaging		0
108	3x35	N - S	rs780394996	similar	3.190e-05	1	31360	Binding site	0	0.951	Damaging		0
110	3x37	F - L	rs1038336613	changed				Binding site	0.03	0.168	Indef.		0
113	3x40	V - I	rs1436884570	similar	3.180e-05	1	31400	Binding site	0.23	0.315	Benign		0
114	3x41	F - L	rs764117616	changed					0	0.973	Damaging		0
116	3x43	I - V	rs768739192	similar					0	0.679	Indef.		0
116	3x43	I - T	rs776867299	changed					0	0.988	Damaging		0
117	3x44	G - C	rs761977053	changed					0.01	0.617	Indef.		0
119	3x46	I - T	rs1322947944	changed	3.180e-05	1	31404		0	0.998	Damaging		0
123	3x50	R - H	rs762976630	similar	3.180e-05	1	31400	CM: ionic lock	0.03	0.537	Indef.		0
123	3x50	R - C	rs370185503	changed				CM: ionic lock	0.06	0.638	Benign		0
124	3x51	C - Y	rs930013266	changed					0	1	Damaging		0
125	3x52	I - V	rs766456681	similar					0.34	0.058	Benign		0
127	3x54	V - L	rs75905426	similar	1.528e-03	48	31404	Intracellular binding site	0	0.974	Damaging		0
128	3x55	L - R	rs886383123	changed				Intracellular binding site	0.05	0.983	Damaging		0
131	34x51	V - A	rs759322229	similar				Intracellular binding site	0.06	0.248	Benign		0
133	34x53	A - V	rs767246581	similar				Intracellular binding site	0.08	0.458	Benign		0
136	34x56	H - Y	rs576326023	changed				Intracellular binding site	0.04	0.768	Indef.		0
136	34x56	H - N	rs576326023	changed				Intracellular binding site	0.04	0.768	Indef.		0
137	34x57	R - H	rs144927349	similar	2.867e-04	9	31396	Intracellular binding site	0.06	0.96	Indef.		0
137	34x57	R - C	rs763580618	changed	3.180e-05	1	31398	Intracellular binding site	0	0.969	Damaging		0
143	4x43	M - T	rs1374410251	changed					0.3	0	Benign		0
143	4x43	M - L	rs758871498	similar	6.370e-05	2	31396		0.02	0	Indef.		0
144	4x44	K - T	rs780662264	changed					0.02	0.756	Indef.		0
147	4x47	V - F	rs201613967	changed					0.15	0.015	Benign		0
147	4x47	V - I	rs201613967	similar	2.548e-04	8	31392		0.15	0.015	Benign		0
148	4x48	G - R	rs529128829	changed					0.04	0.842	Indef.		0
149	4x49	P - L	rs1381842916	changed					0.48	0.029	Benign		0
149	4x49	P - T	rs1210873063	changed	6.370e-05	2	31408		0.27	0.506	Benign		0
152	4x52	L - F	rs144306253	changed					0.22	0.232	Benign		0
159	4x60	P - S	rs1257523118	changed					0	0.639	Indef.		0
162	4x63	L - H	rs778748775	changed					0	0.886	Indef.		0
167		V - A	rs1264253969	similar					0.24	0.013	Benign		0
168		T - I	rs1191951368	changed					0.2	0.022	Benign		0
168		T - A	rs1428770955	changed					0.64	0.015	Benign		0
172		G - R	rs1405225762	changed					0.09	0.927	Indef.		0
173		D - N	rs752040298	changed					1	0.001	Benign		0
174		T - I	rs755457458	changed					0.45	0.019	Benign		0
175		Y - H	rs202141015	changed					0.4	0.02	Benign		0
175		Y - N	rs202141015	changed					0.4	0.02	Benign		0
177	45x51	T - N	rs1225401298	similar				Binding site	0.33	0.021	Benign		0
181		A - S	rs145770786	changed					0.79	0.006	Benign		0
181		A - T	rs145770786	changed					0.79	0.006	Benign		0
184		G - D	rs1208579377	changed					0.02	0.678	Indef.		0
186		T - N	rs745804962	similar	3.190e-05	1	31392		0.23	0.119	Benign		0
189		E - D	rs1215527370	similar					0.06	0.084	Benign		0
192		K - N	rs1379290418	changed	3.180e-05	1	31398		0.22	0.02	Benign		0
196	5x34	T - I	rs200923071	changed	6.370e-05	2	31400		0.22	0.038	Benign		0
196	5x34	T - S	rs200923071	similar					0.22	0.038	Benign		0
197	5x35	M - V	rs371397137	similar					0.65	0.001	Benign		0
197	5x35	M - L	rs371397137	similar					0.65	0.001	Benign		0
205	5x43	R - W	rs761462518	changed				Binding site	0.07	0.299	Benign		0
205	5x43	R - Q	rs138440882	changed	2.548e-04	8	31392	Binding site	0.07	0.919	Indef.		0
208	5x46	I - S	rs1452767722	changed					0	0.906	Indef.		0
213	5x50	P - L	rs141356657	changed	1.274e-04	4	31388		0.03	0.991	Damaging		0
216	5x53	I - T	rs1159394552	changed	3.190e-05	1	31388		0.25	0.113	Benign		0
222	5x59	G - R	rs531939913	changed					0	0.998	Damaging		0
222	5x59	G - E	rs1317950961	changed					0	0.996	Damaging		0
223	5x60	L - F	rs1216306730	changed					0.01	0.99	Damaging		0
224	5x61	I - V	rs1284273058	similar				Intracellular binding site	0.1	0.361	Benign		0
226	5x63	A - V	rs907762465	similar					0.13	0.119	Benign		0
227	5x64	K - R	rs1222700986	similar				Intracellular binding site	0.18	0.232	Benign		0
228	5x65	I - V	rs1487218201	similar				Intracellular binding site	0.07	0.124	Benign		0
231	5x68	K - T	rs757476454	changed				Intracellular binding site	0.08	0.082	Benign		0
232		G - S	rs1408592049	changed	3.190e-05	1	31396	Intracellular binding site	0.14	0.033	Benign		0
232		G - R	rs1408592049	changed				Intracellular binding site	0.14	0.033	Benign		0
232		G - V	rs779046091	changed				Intracellular binding site	0.01	0.616	Indef.		0
238	6x32	R - L	rs199892175	changed				Intracellular binding site	0	0.977	Damaging		0
238	6x32	R - S	rs866790761	changed				Intracellular binding site	0.03	0.643	Indef.		0
238	6x32	R - H	rs199892175	similar	3.180e-05	1	31406	Intracellular binding site	0	0.977	Damaging		0
240	6x34	L - F	rs1040331070	changed	3.180e-05	1	31412		0.46	0.019	Benign		0
241	6x35	R - W	rs772024580	changed	3.180e-05	1	31410		0.11	0.344	Benign		0
241	6x35	R - Q	rs746551181	changed	6.370e-05	2	31410		0.06	0.812	Benign		0
243	6x37	L - F	rs1300463753	changed				Intracellular binding site	0.04

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