GPCRmd

GPCRmd dataset

Class A (Rhodopsin)

Aminergic receptors

5-Hydroxytryptamine receptors

5-HT_1A receptor

5-HT_1B receptor

4IAQ

Apoform: 5-hydroxytryptamine receptor 1B (ID 85)

4IAR

Apoform: 5-hydroxytryptamine receptor 1B (ID 87)

Complex: 5-hydroxytryptamine receptor 1B in complex with ergotamine (ID 90)

5-HT_1D receptor

5-ht_1E receptor

5-HT_1F receptor

5-HT_2A receptor

5-HT_2B receptor

4IB4

Apoform: 5-hydroxytryptamine receptor 2B (ID 92)

Complex: 5-hydroxytryptamine receptor 2B in complex with ergotamine (ID 94)

5-HT_2C receptor

5-HT₄ receptor

5-HT_5A receptor

5-ht_5b receptor

5-HT₆ receptor

5-HT₇ receptor

Acetylcholine receptors (muscarinic)

M₁ receptor

5CXV

Apoform: Muscarinic acetylcholine receptor M1 (ID 154)

Complex: Muscarinic acetylcholine receptor M1 in complex with Tiotropium (ID 194)

M₂ receptor

4MQS

Apoform: Muscarinic acetylcholine receptor M2 (ID 68)

Complex: Muscarinic acetylcholine receptor M2 in complex with iperoxo (ID 69)

4MQT

Apoform: Muscarinic acetylcholine receptor M2 (ID 72)

3UON

Apoform: Muscarinic acetylcholine receptor M2 (ID 111)

Complex: Muscarinic acetylcholine receptor M2 in complex with QUINUCLIDINYL BENZILATE (ID 112)

M₃ receptor

4U15

Apoform: Muscarinic acetylcholine receptor M3 (ID 93)

Complex: Muscarinic acetylcholine receptor M3 in complex with Tiotropium (ID 174)

4U16

Apoform: Muscarinic acetylcholine receptor M3 (ID 175)

Complex: Muscarinic acetylcholine receptor M3 in complex with Paminereg (ID 176)

M₄ receptor

5DSG

Apoform: Muscarinic acetylcholine receptor M4 (ID 157)

Complex: Muscarinic acetylcholine receptor M4 in complex with Tiotropium (ID 173)

M₅ receptor

Adrenoceptors

α_1A-adrenoceptor

α_1B-adrenoceptor

α_1D-adrenoceptor

α_2A-adrenoceptor

α_2B-adrenoceptor

α_2C-adrenoceptor

β₁-adrenoceptor

4AMJ

Apoform: Beta-1 adrenergic receptor (ID 141)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 142)

Complex: Beta-1 adrenergic receptor (ID 167)

Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with (S)-Carvedilol (ID 195)

4BVN

Complex: Partially thermostabilized Beta-1 adrenergic receptor (ID 58)

Apoform: Beta-1 adrenergic receptor (ID 143)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 144)

4AMI

Apoform: Beta-1 adrenergic receptor (ID 138)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 139)

Complex: Partially thermostabilized Beta-1 adrenergic receptor (ID 140)

2YCW

Apoform: Beta-1 adrenergic receptor (ID 56)

Complex: Beta-1 adrenergic receptor complex with carazolol (ID 57)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 64)

3ZPQ

Apoform: Beta-1 adrenergic receptor (ID 131)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 132)

Complex: Beta-1 adrenergic receptor in complex with 4-(1-Piperazinyl)-1H-indole (ID 133)

Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with 4-(1-Piperazinyl)-1H-indole (ID 134)

5A8E

Apoform: Beta-1 adrenergic receptor (ID 147)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 148)

Complex: Beta-1 adrenergic receptor in complex with XTK (ID 149)

Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with XTK (ID 150)

2Y00

Apoform: Beta-1 adrenergic receptor (ID 13)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 14)

Complex: Beta-1 adrenergic receptor in complex with R-dobutamine (ID 15)

Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with (R)-dobutamine (ID 16)

3ZPR

Apoform: Beta-1 adrenergic receptor (ID 135)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 136)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 137)

2Y03

Apoform: Beta-1 adrenergic receptor (ID 23)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 24)

Complex: Beta-1 adrenergic receptor in complex with levisoprenaline (ID 25)

Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with levisoprenaline (ID 26)

2Y02

Apoform: Beta-1 adrenergic receptor (ID 17)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 18)

Complex: Beta-1 adrenergic receptor in complex with carmoterol (ID 19)

Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with carmoterol (ID 20)

2Y04

Apoform: Beta-1 adrenergic receptor (ID 27)

Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 28)

Complex: Beta-1 adrenergic receptor in complex with levalbuterol (ID 29)

Complex: Beta-1 adrenergic receptor in complex with levalbuterol (ID 55)

β₂-adrenoceptor

4LDO

Apoform: Beta-2 adrenergic receptor (ID 116)

Complex: Beta-2 adrenergic receptor in complex with epinephrine (ID 117)

3NYA

Apoform: Beta-2 adrenergic receptor (ID 100)

Complex: Beta-2 adrenergic receptor in complex with (-)-Alprenolol (ID 124)

3NY8

Apoform: Beta-2 adrenergic receptor (ID 88)

Complex: Beta-2 adrenergic receptor in complex with ICI-118551 (ID 123)

4LDE

Apoform: Beta-2 adrenergic receptor (ID 113)

Complex: Beta-2 adrenergic receptor in complex with 8-[(1r)-2-{[1,1-Dimethyl-2-(2-Methylphenyl)ethyl]amino... (ID 121)

3D4S

Apoform: Beta-2 adrenergic receptor (ID 65)

Complex: Beta-2 adrenergic receptor in complex with Aquanil (ID 83)

3NY9

Apoform: Beta-2 adrenergic receptor (ID 96)

Complex: Beta-2 adrenergic receptor in complex with CHEMBL1233771 (ID 99)

3PDS

Apoform: Beta-2 adrenergic receptor (ID 107)

4QKX

Apoform: Beta-2 adrenergic receptor (ID 82)

4LDL

Apoform: Beta-2 adrenergic receptor (ID 114)

Complex: Beta-2 adrenergic receptor in complex with CHEMBL1160696 (ID 115)

2RH1

Apoform: Beta-2 adrenergic receptor (ID 11)

5JQH

Apoform: Beta-2 adrenergic receptor (ID 159)

Complex: Beta-2 adrenergic receptor in complex with (S)-carozol (ID 160)

β₃-adrenoceptor

Dopamine receptors

D₁ receptor

D₂ receptor

D₃ receptor

3PBL

Apoform: D(3) dopamine receptor (ID 105)

Complex: D(3) dopamine receptor in complex with Eticlopride (ID 106)

D₄ receptor

D₅ receptor

Histamine receptors

H₁ receptor

3RZE

Apoform: Histamine H1 receptor (ID 108)

Complex: Histamine H1 receptor in complex with doxepin (ID 109)

Complex: Histamine H1 receptor in complex with Z-doxepin (ID 126)

H₂ receptor

H₃ receptor

H₄ receptor

Trace amine receptors

Peptide receptors

Angiotensin receptors

AT₁ receptor

4ZUD

Complex: Type-1 angiotensin II receptor with olmesartan (ID 120)

Complex: Type-1 angiotensin II receptor (ID 146)

Apoform: Type-1 angiotensin II receptor (ID 189)

Complex: Type-1 angiotensin II receptor in complex with olmesartan (ID 190)

4YAY

Apoform: Type-1 angiotensin II receptor (ID 166)

AT₂ receptor

Apelin receptors

Bombesin receptors

Bradykinin receptors

Cholecystokinin receptors

Complement peptide receptors

Endothelin receptors

ET_A receptor

ET_B receptor

5GLH

Apoform: Endothelin B receptor (ID 158)

Complex: Endothelin B receptor in complex with Endothelin-1 (ID 168)

Formylpeptide receptors

Galanin receptors

Ghrelin receptors

Gonadotrophin-releasing hormone receptors

Kisspeptin receptors

Melanin-concentrating hormone

Melanocortin receptors

Motilin receptors

Neuromedin U receptors

Neuropeptide FF/neuropeptide AF receptors

Neuropeptide S receptors

Neuropeptide W/neuropeptide B receptors

Neuropeptide Y receptors

Neurotensin receptors

NTS₁ receptor

4GRV

Apoform: Neurotensin receptor type 1 (ID 66)

Complex: Neurotensin receptor type 1 in complex with neurotensin (ID 71)

4XEE

Apoform: Neurotensin receptor type 1 (ID 177)

Complex: Neurotensin receptor type 1 in complex with Neurotensin (ID 178)

NTS₂ receptor

Opioid receptors

δ receptor

4RWD

Apoform: Delta-type opioid receptor (ID 84)

4N6H

Apoform: Delta-type opioid receptor (ID 73)

Complex: Delta-type opioid receptor in complex with Naltrindole (ID 145)

κ receptor

4DJH

Apoform: Kappa-type opioid receptor (ID 59)

Complex: Kappa-type opioid receptor in complex with JDTic (ID 60)

μ receptor

5C1M

Apoform: Mu-type opioid receptor (ID 151)

Complex: Mu-type opioid receptor in complex with BU72 (ID 169)

4DKL

Apoform: Mu-type opioid receptor (ID 61)

NOP receptor

5DHG

Apoform: Nociceptin receptor (ID 156)

4EA3

Apoform: Nociceptin receptor (ID 62)

Complex: Nociceptin receptor in complex with 1-benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-y... (ID 70)

5DHH

Apoform: Nociceptin receptor (ID 155)

Orexin receptors

OX₁ receptor

4ZJ8

Apoform: Orexin receptor type 1 (ID 186)

Complex: Orexin receptor type 1 in complex with suvorexant (ID 187)

4ZJC

Complex: Orexin receptor type 1 in complex with sb-674042 (ID 188)

OX₂ receptor

4S0V

Apoform: Orexin receptor type 2 (ID 91)

Complex: Orexin receptor type 2 in complex with Suvorexant (ID 172)

Peptide P518 receptors

Prolactin-releasing peptide receptors

Proteinase-activated receptors

PAR1

3VW7

Apoform: Proteinase-activated receptor 1 (ID 128)

Complex: Proteinase-activated receptor 1 (ID 129)

Complex: Proteinase-activated receptor 1 in complex with Vorapaxar (ID 130)

PAR2

PAR3

PAR4

Relaxin family peptide receptors

Somatostatin receptors

Tachykinin receptors

Thyrotropin-releasing hormone receptors

Urotensin receptors

Vasopressin and oxytocin receptors

Protein receptors

Chemerin receptor

Chemokine receptors

CCR1

CCR2

CCR3

CCR4

CCR5

4MBS

Complex: C-C chemokine receptor type 5 in complex with maravirocum (ID 67)

Apoform: C-C chemokine receptor type 5 (ID 118)

Complex: C-C chemokine receptor type 5 in complex with maravirocum (ID 119)

CCR6

CCR7

CCR8

CCR9

CCR10

CXCR1

CXCR2

CXCR3

CXCR4

3ODU

Apoform: C-X-C chemokine receptor type 4 (ID 101)

Complex: C-X-C chemokine receptor type 4 in complex with IT1t (ID 102)

Complex: C-X-C chemokine receptor type 4 in complex with 1t (ID 103)

4RWS

Complex: C-X-C chemokine receptor type 4 in complex with vMIP-II W5C mutant. (ID 86)

Complex: C-X-C chemokine receptor type 4 in complex with vMIP-II W5C mutant. (ID 89)

Apoform: C-X-C chemokine receptor type 4 (ID 98)

3OE0

Apoform: C-X-C chemokine receptor type 4 (ID 104)

CXCR5

CXCR6

CX₃CR1

XCR1

ACKR1

ACKR2

ACKR3

ACKR4

CCRL2

Glycoprotein hormone receptors

Prokineticin receptors

Lipid receptors

Free fatty acid receptors

FFA1 receptor

4PHU

Apoform: Free fatty acid receptor 1 (ID 75)

Complex: Free fatty acid receptor 1 in complex with TAK-875 (ID 76)

FFA2 receptor

FFA3 receptor

FFA4 receptor

GPR42

Leukotriene receptors

Lysophospholipid (LPA) receptors

LPA₁ receptor

4Z34

Apoform: Lysophosphatidic acid receptor 1 (ID 171)

Complex: Lysophosphatidic acid receptor 1 in complex with ono9780307 (ID 183)

4Z35

Apoform: Lysophosphatidic acid receptor 1 (ID 184)

4Z36

Complex: Lysophosphatidic acid receptor 1 in complex withi ono-3080573 (ID 185)

LPA₂ receptor

LPA₃ receptor

LPA₄ receptor

LPA₅ receptor

LPA₆ receptor

Lysophospholipid (S1P) receptors

S1P₁ receptor

3V2Y

Apoform: Sphingosine 1-phosphate receptor 1 (ID 63)

Complex: Sphingosine 1-phosphate receptor 1 in complex with W146 (ID 127)

S1P₂ receptor

S1P₃ receptor

S1P₄ receptor

S1P₅ receptor

Cannabinoid receptors

CB₁ receptor

5U09

Complex: Cannabinoid receptor 1 in complex with taranabant (ID 22)

Apoform: Cannabinoid receptor 1 (ID 163)

Complex: Cannabinoid receptor 1 in complex with Taranabant (ID 164)

5TGZ

Apoform: Cannabinoid receptor 1 (ID 162)

CB₂ receptor

GPR18, GPR55 and GPR119

Platelet-activating factor receptors

Prostanoid receptors

Melatonin receptors

Nucleotide receptors

Adenosine receptors

A₁ receptor

5UEN

Apoform: Adenosine receptor A1 (ID 21)

Apoform: Adenosine receptor A1 (ID 165)

A_2A receptor

3UZC

Apoform: Adenosine receptor A2a (ID 41)

Complex: Adenosine receptor A2a in complex with 4-(3-Amino-5-phenyl-1,2,4-triazine-6-yl)-2-chlorophenol (ID 42)

4UHR

Apoform: Adenosine receptor A2a (ID 45)

Complex: Adenosine receptor A2a in complex CGS-21680 (ID 46)

3RFM

Apoform: Adenosine receptor A2a (ID 37)

Complex: Adenosine receptor A2a in complex with caffeine (ID 38)

5IU8

Apoform: Adenosine receptor A2a (ID 52)

3UZA

Apoform: Adenosine receptor A2a (ID 39)

Complex: Adenosine receptor A2a in complex with 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine (ID 40)

5IU4

Apoform: Adenosine receptor A2a (ID 49)

Complex: Adenosine receptor A2a in complex with ZM241385 (ID 50)

2YDV

Apoform: Adenosine receptor A2a (ID 32)

Complex: Adenosine receptor A2a in complex with NECA (ID 33)

4EIY

Apoform: Adenosine receptor A2a (ID 43)

Complex: Adenosine receptor A2a in complex with ZM241385 (ID 44)

5G53

Apoform: Adenosine receptor A2a (ID 47)

Complex: Adenosine receptor A2a in complex with N-ethyl-5'-carboxamido adenosine (ID 48)

5IU7

Apoform: Adenosine receptor A2a (ID 51)

3REY

Apoform: Adenosine receptor A2a (ID 35)

Complex: Adenosine receptor A2a in complex with xanthine amine congener (ID 36)

5IUB

Apoform: Adenosine receptor A2a (ID 54)

3QAK

Apoform: Adenosine receptor A2a (ID 34)

2YDO

Apoform: Adenosine receptor A2a (ID 30)

Complex: Adenosine receptor A2a in complex with adenosine (ID 31)

5IUA

Apoform: Adenosine receptor A2a (ID 53)

A_2B receptor

A₃ receptor

P2Y receptors

P2Y₁ receptor

4XNW

Apoform: P2Y purinoceptor 1 (ID 180)

Complex: P2Y purinoceptor 1 in complex with mrs-2500 (ID 181)

Complex: P2Y purinoceptor 1 in complex with mrs-2500 (ID 182)

4XNV

Apoform: P2Y purinoceptor 1 (ID 179)

P2Y₂ receptor

P2Y₄ receptor

P2Y₆ receptor

P2Y₁₁ receptor

P2Y₁₂ receptor

4PXZ

Apoform: P2Y purinoceptor 12 (ID 77)

Complex: P2Y purinoceptor 12 in complex with Methylthio-adenosine diphosphate (ID 78)

4PY0

Apoform: P2Y purinoceptor 12 (ID 79)

Complex: P2Y purinoceptor 12 in complex with 2-Mesatp (ID 80)

P2Y₁₃ receptor

P2Y₁₄ receptor

Steroid receptors

Alicarboxylic acid receptors

Sensory receptors

Opsins

Rhodopsin

1U19

Apoform: Rhodopsin (ID 12)

3DQB

Apoform: Rhodopsin (ID 122)

3PQR

Apoform: Rhodopsin (ID 125)

Melanopsin

Opsin-3

Opsin-5

Short-wave-sensitive opsin 1

Medium-wave-sensitive opsin 1

Long-wave-sensitive opsin 1

Orphan receptors

Other

Unclassified

US28

4XT1

Apoform: G-protein coupled receptor homolog US28 (ID 170)

Class B1 (Secretin)

Peptide receptors

Calcitonin receptors

Corticotropin-releasing factor receptors

CRF₁ receptor

4K5Y

Apoform: Corticotropin-releasing factor receptor 1 (ID 95)

Complex: Corticotropin-releasing factor receptor 1 in complex with CP-376395 (ID 97)

CRF₂ receptor

Glucagon receptor family

GHRH receptor

GIP receptor

GLP-1 receptor

GLP-2 receptor

glucagon receptor

4L6R

Apoform: Glucagon receptor (ID 110)

secretin receptor

Parathyroid hormone receptors

VIP and PACAP receptors

Class B2 (Adhesion)

Class C (Glutamate)

Ion receptors

Amino acid receptors

GABA_B receptors

Metabotropic glutamate receptors

mGlu₁ receptor

4OR2

Apoform: Metabotropic glutamate receptor 1 (ID 81)

mGlu₂ receptor

mGlu₃ receptor

mGlu₄ receptor

mGlu₅ receptor

5CGC

Apoform: Metabotropic glutamate receptor 5 (ID 152)

4OO9

Apoform: Metabotropic glutamate receptor 5 (ID 74)

5CGD

Apoform: Metabotropic glutamate receptor 5 (ID 153)

Complex: Metabotropic glutamate receptor 5 in complex with HTL14242 (ID 193)

mGlu₆ receptor

mGlu₇ receptor

mGlu₈ receptor

Sensory receptors

Orphan receptors

Class F (Frizzled)

Protein receptors

Frizzled

FZD₁

FZD₂

FZD₃

FZD₄

FZD₅

FZD₆

FZD₇

FZD₈

FZD₉

FZD₁₀

SMO

5L7I

Apoform: Smoothened homolog (ID 191)

Complex: Smoothened homolog in complex with Vismodegib (ID 192)

5L7D

Apoform: Smoothened homolog (ID 161)

Taste 2

Other GPCRs

Individual contributions

Class A (Rhodopsin)

Aminergic receptors

5-Hydroxytryptamine receptors

Acetylcholine receptors (muscarinic)

Adrenoceptors

α_1A-adrenoceptor

α_1B-adrenoceptor

α_1D-adrenoceptor

α_2A-adrenoceptor

α_2B-adrenoceptor

α_2C-adrenoceptor

β₁-adrenoceptor

β₂-adrenoceptor

2R4R

Complex: Beta 2 Adrenergic Receptor & Carazolol (ID 6) - GPCR drug discovery group (Pompeu Fabra University)

Complex: Beta 2 adrenergic receptor and carazolol (ID 10) - GPCR drug discovery group (Pompeu Fabra University)

Complex: Beta 2 adrenergic receptor and isoproterenol (ID 9) - GPCR drug discovery group (Pompeu Fabra University)

β₃-adrenoceptor

Dopamine receptors

Histamine receptors

Trace amine receptors

Peptide receptors

Angiotensin receptors

Apelin receptors

Bombesin receptors

Bradykinin receptors

Cholecystokinin receptors

Complement peptide receptors

Endothelin receptors

Formylpeptide receptors

Galanin receptors

Ghrelin receptors

Gonadotrophin-releasing hormone receptors

Kisspeptin receptors

Melanin-concentrating hormone

Melanocortin receptors

Motilin receptors

Neuromedin U receptors

Neuropeptide FF/neuropeptide AF receptors

Neuropeptide S receptors

Neuropeptide W/neuropeptide B receptors

Neuropeptide Y receptors

Neurotensin receptors

Opioid receptors

δ receptor

4N6H

Complex: Delta Opioid with Naltrindole (ID 4) - GPCR drug discovery group (Pompeu Fabra University)

Complex: delta opioid receptor (human) (ID 8) - GPCR drug discovery group (Pompeu Fabra University)

κ receptor

μ receptor

5C1M

Complex: Active mu-opioid receptor bound to the agonist morphine (ID 199) - Marta Filizola, Icahn School of Medicine at Mout Sinai

Complex: Mu-type opioid receptor bound to Oliceridine (ID 201) - Marta Filizola, Icahn School of Medicine at Mout Sinai

NOP receptor

Orexin receptors

Peptide P518 receptors

Prolactin-releasing peptide receptors

Proteinase-activated receptors

Relaxin family peptide receptors

Somatostatin receptors

Tachykinin receptors

Thyrotropin-releasing hormone receptors

Urotensin receptors

Vasopressin and oxytocin receptors

Protein receptors

Lipid receptors

Melatonin receptors

Nucleotide receptors

Adenosine receptors

A₁ receptor

A_2A receptor

3EML

Complex: A2a Adenosine receptor & Cholesterol (ID 7) - GPCR drug discovery group (Pompeu Fabra University)

A_2B receptor

A₃ receptor

P2Y receptors

Steroid receptors

Alicarboxylic acid receptors

Sensory receptors

Opsins

Rhodopsin

4J4Q

Apoform: active conformation of GPCR opsin stabilized by octylglucoside (ID 197) - George Khelashvili, Weill Cornell Medical College

Melanopsin

Opsin-3

Opsin-5

Short-wave-sensitive opsin 1

Medium-wave-sensitive opsin 1

Long-wave-sensitive opsin 1

Orphan receptors

Other

Class B1 (Secretin)

Class B2 (Adhesion)

Class C (Glutamate)

Class F (Frizzled)

Protein receptors

Frizzled

FZD₁

FZD₂

FZD₃

FZD₄

6BD4

Apoform: human apo-Frizzled4 receptor (ID 196) - Ainoleena Turku, Karolinska Institutet

FZD₅

FZD₆

HOMO

Complex: active-like FZD6 SAG1.3-bound (ID 205) - Ainoleena Turku, Karolinska Institutet

Complex: inactive FZD6 bound to Smoothened agonist (ID 202) - Ainoleena Turku, Karolinska Institutet

FZD₇

FZD₈

FZD₉

FZD₁₀

SMO

4QIN

Apoform: human smoothened receptor (ID 198) - Ainoleena Turku, Karolinska Institutet

Apoform: human smoothened receptor (ID 200) - Ainoleena Turku, Karolinska Institutet

Complex: human smoothened receptor in complex with SAG (ID 203) - Ainoleena Turku, Karolinska Institutet

Complex: human smoothened receptor in complex with SAG (ID 204) - Ainoleena Turku, Karolinska Institutet

Taste 2

Other GPCRs