GPCRmd dataset

Class A (Rhodopsin)
Aminergic receptors
5-Hydroxytryptamine receptors
5-HT1A receptor
5-HT1B receptor
4IAQ
Apoform: 5-hydroxytryptamine receptor 1B (ID 85)
4IAR
Apoform: 5-hydroxytryptamine receptor 1B (ID 87)
Complex: 5-hydroxytryptamine receptor 1B in complex with ergotamine (ID 90)
5-HT1D receptor
5-ht1E receptor
5-HT1F receptor
5-HT2A receptor
5-HT2B receptor
4IB4
Apoform: 5-hydroxytryptamine receptor 2B (ID 92)
Complex: 5-hydroxytryptamine receptor 2B in complex with ergotamine (ID 94)
5-HT2C receptor
5-HT4 receptor
5-HT5A receptor
5-ht5b receptor
5-HT6 receptor
5-HT7 receptor
Acetylcholine receptors (muscarinic)
M1 receptor
5CXV
Apoform: Muscarinic acetylcholine receptor M1 (ID 154)
Complex: Muscarinic acetylcholine receptor M1 in complex with Tiotropium (ID 194)
M2 receptor
4MQT
Apoform: Muscarinic acetylcholine receptor M2 (ID 72)
4MQS
Apoform: Muscarinic acetylcholine receptor M2 (ID 68)
Complex: Muscarinic acetylcholine receptor M2 in complex with iperoxo (ID 69)
3UON
Apoform: Muscarinic acetylcholine receptor M2 (ID 111)
Complex: Muscarinic acetylcholine receptor M2 in complex with QUINUCLIDINYL BENZILATE (ID 112)
M3 receptor
4U15
Apoform: Muscarinic acetylcholine receptor M3 (ID 93)
Complex: Muscarinic acetylcholine receptor M3 in complex with Tiotropium (ID 174)
4U16
Apoform: Muscarinic acetylcholine receptor M3 (ID 175)
Complex: Muscarinic acetylcholine receptor M3 in complex with Paminereg (ID 176)
M4 receptor
5DSG
Apoform: Muscarinic acetylcholine receptor M4 (ID 157)
Complex: Muscarinic acetylcholine receptor M4 in complex with Tiotropium (ID 173)
M5 receptor
Adrenoceptors
α1A-adrenoceptor
α1B-adrenoceptor
α1D-adrenoceptor
α2A-adrenoceptor
α2B-adrenoceptor
α2C-adrenoceptor
β1-adrenoceptor
3ZPQ
Apoform: Beta-1 adrenergic receptor (ID 131)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 132)
Complex: Beta-1 adrenergic receptor in complex with 4-(1-Piperazinyl)-1H-indole (ID 133)
Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with 4-(1-Piperazinyl)-1H-indole (ID 134)
4AMI
Apoform: Beta-1 adrenergic receptor (ID 138)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 139)
Complex: Partially thermostabilized Beta-1 adrenergic receptor (ID 140)
5A8E
Apoform: Beta-1 adrenergic receptor (ID 147)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 148)
Complex: Beta-1 adrenergic receptor in complex with XTK (ID 149)
Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with XTK (ID 150)
2Y04
Apoform: Beta-1 adrenergic receptor (ID 27)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 28)
Complex: Beta-1 adrenergic receptor in complex with levalbuterol (ID 29)
Complex: Beta-1 adrenergic receptor in complex with levalbuterol (ID 55)
3ZPR
Apoform: Beta-1 adrenergic receptor (ID 135)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 136)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 137)
4BVN
Complex: Partially thermostabilized Beta-1 adrenergic receptor (ID 58)
Apoform: Beta-1 adrenergic receptor (ID 143)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 144)
2Y00
Apoform: Beta-1 adrenergic receptor (ID 13)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 14)
Complex: Beta-1 adrenergic receptor in complex with R-dobutamine (ID 15)
Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with (R)-dobutamine (ID 16)
2Y02
Apoform: Beta-1 adrenergic receptor (ID 17)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 18)
Complex: Beta-1 adrenergic receptor in complex with carmoterol (ID 19)
Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with carmoterol (ID 20)
2Y03
Apoform: Beta-1 adrenergic receptor (ID 23)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 24)
Complex: Beta-1 adrenergic receptor in complex with levisoprenaline (ID 25)
Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with levisoprenaline (ID 26)
2YCW
Apoform: Beta-1 adrenergic receptor (ID 56)
Complex: Beta-1 adrenergic receptor complex with carazolol (ID 57)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 64)
4AMJ
Apoform: Beta-1 adrenergic receptor (ID 141)
Apoform: Partially thermostabilized Beta-1 adrenergic receptor (ID 142)
Complex: Beta-1 adrenergic receptor (ID 167)
Complex: Partially thermostabilized Beta-1 adrenergic receptor in complex with (S)-Carvedilol (ID 195)
β2-adrenoceptor
4LDE
Apoform: Beta-2 adrenergic receptor (ID 113)
Complex: Beta-2 adrenergic receptor in complex with 8-[(1r)-2-{[1,1-Dimethyl-2-(2-Methylphenyl)ethyl]amino... (ID 121)
3NY9
Apoform: Beta-2 adrenergic receptor (ID 96)
Complex: Beta-2 adrenergic receptor in complex with CHEMBL1233771 (ID 99)
3D4S
Apoform: Beta-2 adrenergic receptor (ID 65)
Complex: Beta-2 adrenergic receptor in complex with Aquanil (ID 83)
4QKX
Apoform: Beta-2 adrenergic receptor (ID 82)
3NYA
Apoform: Beta-2 adrenergic receptor (ID 100)
Complex: Beta-2 adrenergic receptor in complex with (-)-Alprenolol (ID 124)
5JQH
Apoform: Beta-2 adrenergic receptor (ID 159)
Complex: Beta-2 adrenergic receptor in complex with (S)-carozol (ID 160)
2RH1
Apoform: Beta-2 adrenergic receptor (ID 11)
4LDL
Apoform: Beta-2 adrenergic receptor (ID 114)
Complex: Beta-2 adrenergic receptor in complex with CHEMBL1160696 (ID 115)
4LDO
Apoform: Beta-2 adrenergic receptor (ID 116)
Complex: Beta-2 adrenergic receptor in complex with epinephrine (ID 117)
3NY8
Apoform: Beta-2 adrenergic receptor (ID 88)
Complex: Beta-2 adrenergic receptor in complex with ICI-118551 (ID 123)
3PDS
Apoform: Beta-2 adrenergic receptor (ID 107)
β3-adrenoceptor
Dopamine receptors
D1 receptor
D2 receptor
D3 receptor
3PBL
Apoform: D(3) dopamine receptor (ID 105)
Complex: D(3) dopamine receptor in complex with Eticlopride (ID 106)
D4 receptor
D5 receptor
Histamine receptors
H1 receptor
3RZE
Apoform: Histamine H1 receptor (ID 108)
Complex: Histamine H1 receptor in complex with doxepin (ID 109)
Complex: Histamine H1 receptor in complex with Z-doxepin (ID 126)
H2 receptor
H3 receptor
H4 receptor
Trace amine receptors
Peptide receptors
Angiotensin receptors
AT1 receptor
4ZUD
Complex: Type-1 angiotensin II receptor with olmesartan (ID 120)
Complex: Type-1 angiotensin II receptor (ID 146)
Apoform: Type-1 angiotensin II receptor (ID 189)
Complex: Type-1 angiotensin II receptor in complex with olmesartan (ID 190)
4YAY
Apoform: Type-1 angiotensin II receptor (ID 166)
AT2 receptor
Apelin receptors
Bombesin receptors
Bradykinin receptors
Cholecystokinin receptors
Complement peptide receptors
Endothelin receptors
ETA receptor
ETB receptor
5GLH
Apoform: Endothelin B receptor (ID 158)
Complex: Endothelin B receptor in complex with Endothelin-1 (ID 168)
Formylpeptide receptors
Galanin receptors
Ghrelin receptors
Gonadotrophin-releasing hormone receptors
Kisspeptin receptors
Melanin-concentrating hormone
Melanocortin receptors
Motilin receptors
Neuromedin U receptors
Neuropeptide FF/neuropeptide AF receptors
Neuropeptide S receptors
Neuropeptide W/neuropeptide B receptors
Neuropeptide Y receptors
Neurotensin receptors
NTS1 receptor
4GRV
Apoform: Neurotensin receptor type 1 (ID 66)
Complex: Neurotensin receptor type 1 in complex with neurotensin (ID 71)
4XEE
Apoform: Neurotensin receptor type 1 (ID 177)
Complex: Neurotensin receptor type 1 in complex with Neurotensin (ID 178)
NTS2 receptor
Opioid receptors
δ receptor
4N6H
Apoform: Delta-type opioid receptor (ID 73)
Complex: Delta-type opioid receptor in complex with Naltrindole (ID 145)
4RWD
Apoform: Delta-type opioid receptor (ID 84)
κ receptor
4DJH
Apoform: Kappa-type opioid receptor (ID 59)
Complex: Kappa-type opioid receptor in complex with JDTic (ID 60)
μ receptor
5C1M
Apoform: Mu-type opioid receptor (ID 151)
Complex: Mu-type opioid receptor in complex with BU72 (ID 169)
4DKL
Apoform: Mu-type opioid receptor (ID 61)
NOP receptor
5DHG
Apoform: Nociceptin receptor (ID 156)
4EA3
Apoform: Nociceptin receptor (ID 62)
Complex: Nociceptin receptor in complex with 1-benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-y... (ID 70)
5DHH
Apoform: Nociceptin receptor (ID 155)
Orexin receptors
OX1 receptor
4ZJC
Complex: Orexin receptor type 1 in complex with sb-674042 (ID 188)
4ZJ8
Apoform: Orexin receptor type 1 (ID 186)
Complex: Orexin receptor type 1 in complex with suvorexant (ID 187)
OX2 receptor
4S0V
Apoform: Orexin receptor type 2 (ID 91)
Complex: Orexin receptor type 2 in complex with Suvorexant (ID 172)
Peptide P518 receptors
Prolactin-releasing peptide receptors
Proteinase-activated receptors
PAR1
3VW7
Apoform: Proteinase-activated receptor 1 (ID 128)
Complex: Proteinase-activated receptor 1 (ID 129)
Complex: Proteinase-activated receptor 1 in complex with Vorapaxar (ID 130)
PAR2
PAR3
PAR4
Relaxin family peptide receptors
Somatostatin receptors
Tachykinin receptors
Thyrotropin-releasing hormone receptors
Urotensin receptors
Vasopressin and oxytocin receptors
Protein receptors
Chemerin receptor
Chemokine receptors
CCR1
CCR2
CCR3
CCR4
CCR5
4MBS
Complex: C-C chemokine receptor type 5 in complex with maravirocum (ID 67)
Apoform: C-C chemokine receptor type 5 (ID 118)
Complex: C-C chemokine receptor type 5 in complex with maravirocum (ID 119)
CCR6
CCR7
CCR8
CCR9
CCR10
CXCR1
CXCR2
CXCR3
CXCR4
3OE0
Apoform: C-X-C chemokine receptor type 4 (ID 104)
3ODU
Apoform: C-X-C chemokine receptor type 4 (ID 101)
Complex: C-X-C chemokine receptor type 4 in complex with IT1t (ID 102)
Complex: C-X-C chemokine receptor type 4 in complex with 1t (ID 103)
4RWS
Complex: C-X-C chemokine receptor type 4 in complex with vMIP-II W5C mutant. (ID 86)
Complex: C-X-C chemokine receptor type 4 in complex with vMIP-II W5C mutant. (ID 89)
Apoform: C-X-C chemokine receptor type 4 (ID 98)
CXCR5
CXCR6
CX3CR1
XCR1
ACKR1
ACKR2
ACKR3
ACKR4
CCRL2
Glycoprotein hormone receptors
Prokineticin receptors
Lipid receptors
Free fatty acid receptors
FFA1 receptor
4PHU
Apoform: Free fatty acid receptor 1 (ID 75)
Complex: Free fatty acid receptor 1 in complex with TAK-875 (ID 76)
FFA2 receptor
FFA3 receptor
FFA4 receptor
GPR42
Leukotriene receptors
Lysophospholipid (LPA) receptors
LPA1 receptor
4Z34
Apoform: Lysophosphatidic acid receptor 1 (ID 171)
Complex: Lysophosphatidic acid receptor 1 in complex with ono9780307 (ID 183)
4Z35
Apoform: Lysophosphatidic acid receptor 1 (ID 184)
4Z36
Complex: Lysophosphatidic acid receptor 1 in complex withi ono-3080573 (ID 185)
LPA2 receptor
LPA3 receptor
LPA4 receptor
LPA5 receptor
LPA6 receptor
Lysophospholipid (S1P) receptors
S1P1 receptor
3V2Y
Apoform: Sphingosine 1-phosphate receptor 1 (ID 63)
Complex: Sphingosine 1-phosphate receptor 1 in complex with W146 (ID 127)
S1P2 receptor
S1P3 receptor
S1P4 receptor
S1P5 receptor
Cannabinoid receptors
CB1 receptor
5TGZ
Apoform: Cannabinoid receptor 1 (ID 162)
5U09
Complex: Cannabinoid receptor 1 in complex with taranabant (ID 22)
Apoform: Cannabinoid receptor 1 (ID 163)
Complex: Cannabinoid receptor 1 in complex with Taranabant (ID 164)
CB2 receptor
GPR18, GPR55 and GPR119
Platelet-activating factor receptors
Prostanoid receptors
Melatonin receptors
Nucleotide receptors
Adenosine receptors
A1 receptor
5UEN
Apoform: Adenosine receptor A1 (ID 21)
Apoform: Adenosine receptor A1 (ID 165)
A2A receptor
5IU8
Apoform: Adenosine receptor A2a (ID 52)
5IU4
Apoform: Adenosine receptor A2a (ID 49)
Complex: Adenosine receptor A2a in complex with ZM241385 (ID 50)
3UZC
Apoform: Adenosine receptor A2a (ID 41)
Complex: Adenosine receptor A2a in complex with 4-(3-Amino-5-phenyl-1,2,4-triazine-6-yl)-2-chlorophenol (ID 42)
3UZA
Apoform: Adenosine receptor A2a (ID 39)
Complex: Adenosine receptor A2a in complex with 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine (ID 40)
5G53
Apoform: Adenosine receptor A2a (ID 47)
Complex: Adenosine receptor A2a in complex with N-ethyl-5'-carboxamido adenosine (ID 48)
3REY
Apoform: Adenosine receptor A2a (ID 35)
Complex: Adenosine receptor A2a in complex with xanthine amine congener (ID 36)
3RFM
Apoform: Adenosine receptor A2a (ID 37)
Complex: Adenosine receptor A2a in complex with caffeine (ID 38)
2YDV
Apoform: Adenosine receptor A2a (ID 32)
Complex: Adenosine receptor A2a in complex with NECA (ID 33)
5IUB
Apoform: Adenosine receptor A2a (ID 54)
5IU7
Apoform: Adenosine receptor A2a (ID 51)
5IUA
Apoform: Adenosine receptor A2a (ID 53)
4EIY
Apoform: Adenosine receptor A2a (ID 43)
Complex: Adenosine receptor A2a in complex with ZM241385 (ID 44)
2YDO
Apoform: Adenosine receptor A2a (ID 30)
Complex: Adenosine receptor A2a in complex with adenosine (ID 31)
3QAK
Apoform: Adenosine receptor A2a (ID 34)
4UHR
Apoform: Adenosine receptor A2a (ID 45)
Complex: Adenosine receptor A2a in complex CGS-21680 (ID 46)
A2B receptor
A3 receptor
P2Y receptors
P2Y1 receptor
4XNV
Apoform: P2Y purinoceptor 1 (ID 179)
4XNW
Apoform: P2Y purinoceptor 1 (ID 180)
Complex: P2Y purinoceptor 1 in complex with mrs-2500 (ID 181)
Complex: P2Y purinoceptor 1 in complex with mrs-2500 (ID 182)
P2Y2 receptor
P2Y4 receptor
P2Y6 receptor
P2Y11 receptor
P2Y12 receptor
4PY0
Apoform: P2Y purinoceptor 12 (ID 79)
Complex: P2Y purinoceptor 12 in complex with 2-Mesatp (ID 80)
4PXZ
Apoform: P2Y purinoceptor 12 (ID 77)
Complex: P2Y purinoceptor 12 in complex with Methylthio-adenosine diphosphate (ID 78)
P2Y13 receptor
P2Y14 receptor
Steroid receptors
Alicarboxylic acid receptors
Sensory receptors
Opsins
Rhodopsin
3DQB
Apoform: Rhodopsin (ID 122)
3PQR
Apoform: Rhodopsin (ID 125)
1U19
Apoform: Rhodopsin (ID 12)
Melanopsin
Opsin-3
Opsin-5
Short-wave-sensitive opsin 1
Medium-wave-sensitive opsin 1
Long-wave-sensitive opsin 1
Orphan receptors
Other
Unclassified
US28
4XT1
Apoform: G-protein coupled receptor homolog US28 (ID 170)
Class B1 (Secretin)
Peptide receptors
Calcitonin receptors
Corticotropin-releasing factor receptors
CRF1 receptor
4K5Y
Apoform: Corticotropin-releasing factor receptor 1 (ID 95)
Complex: Corticotropin-releasing factor receptor 1 in complex with CP-376395 (ID 97)
CRF2 receptor
Glucagon receptor family
GHRH receptor
GIP receptor
GLP-1 receptor
GLP-2 receptor
glucagon receptor
4L6R
Apoform: Glucagon receptor (ID 110)
secretin receptor
Parathyroid hormone receptors
VIP and PACAP receptors
Class B2 (Adhesion)
Class C (Glutamate)
Ion receptors
Amino acid receptors
GABAB receptors
Metabotropic glutamate receptors
mGlu1 receptor
4OR2
Apoform: Metabotropic glutamate receptor 1 (ID 81)
mGlu2 receptor
mGlu3 receptor
mGlu4 receptor
mGlu5 receptor
4OO9
Apoform: Metabotropic glutamate receptor 5 (ID 74)
5CGD
Apoform: Metabotropic glutamate receptor 5 (ID 153)
Complex: Metabotropic glutamate receptor 5 in complex with HTL14242 (ID 193)
5CGC
Apoform: Metabotropic glutamate receptor 5 (ID 152)
mGlu6 receptor
mGlu7 receptor
mGlu8 receptor
Sensory receptors
Orphan receptors
Class F (Frizzled)
Protein receptors
Frizzled
FZD1
FZD2
FZD3
FZD4
FZD5
FZD6
FZD7
FZD8
FZD9
FZD10
SMO
5L7I
Apoform: Smoothened homolog (ID 191)
Complex: Smoothened homolog in complex with Vismodegib (ID 192)
5L7D
Apoform: Smoothened homolog (ID 161)
Taste 2
Other GPCRs

Individual contributions

Class A (Rhodopsin)
Aminergic receptors
5-Hydroxytryptamine receptors
Acetylcholine receptors (muscarinic)
Adrenoceptors
α1A-adrenoceptor
α1B-adrenoceptor
α1D-adrenoceptor
α2A-adrenoceptor
α2B-adrenoceptor
α2C-adrenoceptor
β1-adrenoceptor
β2-adrenoceptor
2R4R
Complex: Beta 2 Adrenergic Receptor & Carazolol (ID 6) - GPCR drug discovery group (Pompeu Fabra University)
Complex: Beta 2 adrenergic receptor and carazolol (ID 10) - GPCR drug discovery group (Pompeu Fabra University)
Complex: Beta 2 adrenergic receptor and isoproterenol (ID 9) - GPCR drug discovery group (Pompeu Fabra University)
β3-adrenoceptor
Dopamine receptors
Histamine receptors
Trace amine receptors
Peptide receptors
Angiotensin receptors
Apelin receptors
Bombesin receptors
Bradykinin receptors
Cholecystokinin receptors
Complement peptide receptors
Endothelin receptors
Formylpeptide receptors
Galanin receptors
Ghrelin receptors
Gonadotrophin-releasing hormone receptors
Kisspeptin receptors
Melanin-concentrating hormone
Melanocortin receptors
Motilin receptors
Neuromedin U receptors
Neuropeptide FF/neuropeptide AF receptors
Neuropeptide S receptors
Neuropeptide W/neuropeptide B receptors
Neuropeptide Y receptors
Neurotensin receptors
Opioid receptors
δ receptor
4N6H
Complex: Delta Opioid with Naltrindole (ID 4) - GPCR drug discovery group (Pompeu Fabra University)
Complex: delta opioid receptor (human) (ID 8) - GPCR drug discovery group (Pompeu Fabra University)
κ receptor
μ receptor
5C1M
Complex: Active mu-opioid receptor bound to the agonist morphine (ID 199) - Marta Filizola, Icahn School of Medicine at Mout Sinai
Complex: Mu-type opioid receptor bound to Oliceridine (ID 201) - Marta Filizola, Icahn School of Medicine at Mout Sinai
NOP receptor
Orexin receptors
Peptide P518 receptors
Prolactin-releasing peptide receptors
Proteinase-activated receptors
Relaxin family peptide receptors
Somatostatin receptors
Tachykinin receptors
Thyrotropin-releasing hormone receptors
Urotensin receptors
Vasopressin and oxytocin receptors
Protein receptors
Lipid receptors
Melatonin receptors
Nucleotide receptors
Adenosine receptors
A1 receptor
A2A receptor
3EML
Complex: A2a Adenosine receptor & Cholesterol (ID 7) - GPCR drug discovery group (Pompeu Fabra University)
A2B receptor
A3 receptor
P2Y receptors
Steroid receptors
Alicarboxylic acid receptors
Sensory receptors
Opsins
Rhodopsin
4J4Q
Apoform: active conformation of GPCR opsin stabilized by octylglucoside (ID 197) - George Khelashvili, Weill Cornell Medical College
Melanopsin
Opsin-3
Opsin-5
Short-wave-sensitive opsin 1
Medium-wave-sensitive opsin 1
Long-wave-sensitive opsin 1
Orphan receptors
Other
Class B1 (Secretin)
Class B2 (Adhesion)
Class C (Glutamate)
Class F (Frizzled)
Protein receptors
Frizzled
FZD1
FZD2
FZD3
FZD4
6BD4
Apoform: human apo-Frizzled4 receptor (ID 196) - Ainoleena Turku, Karolinska Institutet
FZD5
FZD6
HOMO
Complex: active-like FZD6 SAG1.3-bound (ID 205) - Ainoleena Turku, Karolinska Institutet
Complex: inactive FZD6 bound to Smoothened agonist (ID 202) - Ainoleena Turku, Karolinska Institutet
FZD7
FZD8
FZD9
FZD10
SMO
4QIN
Apoform: human smoothened receptor (ID 198) - Ainoleena Turku, Karolinska Institutet
Apoform: human smoothened receptor (ID 200) - Ainoleena Turku, Karolinska Institutet
Complex: human smoothened receptor in complex with SAG (ID 203) - Ainoleena Turku, Karolinska Institutet
Complex: human smoothened receptor in complex with SAG (ID 204) - Ainoleena Turku, Karolinska Institutet
Taste 2
Other GPCRs