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Complex Info:
Proteins used in this complex:
Adenosine receptor A2a (Homo sapiens)

Orthosteric ligand(s) in this complex:



Efficacy values:
EC50 according to BindingDB: 13.0 nM Original page
EC50 according to BindingDB: 13.0 nM Original page

Complex structures in which this complex is used:

Complex Structure ID: 45 using Specific State(s): Specific State ID: 1688


Complex Structure ID: 30 using Specific State(s): Specific State ID: 1688




References for this complex:

Preti, D; Baraldi, PG; Saponaro, G; Romagnoli, R; Aghazadeh Tabrizi, M; Baraldi, S; Cosconati, S; Bruno, A; Novellino, E; Vincenzi, F; Ravani, A; Borea, PA; Varani, K. 2015. Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.. Journal of medicinal chemistry 58 (7). doi: 10.1021/acs.jmedchem.5b00215. Available in: Pubmed Link




Preti, D; Baraldi, PG; Saponaro, G; Romagnoli, R; Aghazadeh Tabrizi, M; Baraldi, S; Cosconati, S; Bruno, A; Novellino, E; Vincenzi, F; Ravani, A; Borea, PA; Varani, K. 2015. Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.. Journal of medicinal chemistry 58 (7). doi: 10.1021/acs.jmedchem.5b00215. Available in: Pubmed Link